Siddharth Sinha
Post Doctorate Fellow
Education:
B.tech in Biotechnology, Amity University, Noida, India, 2004 – 2008
Ph.D in Biotechnology, TERI University, Delhi, India, 2013 – 2017
Work experience:
Post-doctoral Fellow, Faculty of Health Sciences, University of Macau. 1st Nov 2017-Present
Ph.D. Scholar, Department of Biotechnology, TERI University, India. Aug 2013- Oct 2017
Research Analyst, Bioinformatics Centre, BIOTECH PARK, India. Dec 2012- July 2013
Scientist, ACS-bioINFORMTICS Ltd, Lucknow, India. Aug 2008- Aug 2012
Publications:
1. Sinha S, Qin Z, Tam B, Wang SM. Identification of deleterious variants of uncertain significance in BRCA2 BRC4 repeat through molecular dynamics simulations. Brief Funct Genomics. 2022 May 21;21(3):202-215. doi: 10.1093/bfgp/elac003. PubMed PMID: 35325018.
2. Sinha S, Tam B, Wang SM. RBD Double Mutations of SARS-CoV-2 Strains Increase Transmissibility through Enhanced Interaction between RBD and ACE2 Receptor. Viruses. 2021 Dec 21;14(1). doi: 10.3390/v14010001. PubMed PMID: 35062205; PubMed Central PMCID: PMC8781274.
3. Tam B, Sinha S, Qin Z, Wang SM. Comprehensive Identification of Deleterious TP53 Missense VUS Variants Based on Their Impact on TP53 Structural Stability. Int J Mol Sci. 2021 Oct 20;22(21). doi: 10.3390/ijms222111345. PubMed PMID: 34768775; PubMed Central PMCID: PMC8583684.
4. Chian J, Sinha S, Qin Z, Wang SM. BRCA1 and BRCA2 Variation in Taiwanese General Population and the Cancer Cohort. Front Mol Biosci. 2021;8:685174. doi: 10.3389/fmolb.2021.685174. eCollection 2021. PubMed PMID: 34235180; PubMed Central PMCID: PMC8256441.
5. Tam B, Sinha S, Wang SM. Combining Ramachandran plot and molecular dynamics simulation for structural-based variant classification: Using TP53 variants as model. Comput Struct Biotechnol J.2020;18:4033-4039. doi: 10.1016/j.csbj.2020.11.041. eCollection 2020. PubMed PMID: 33363700; PubMed Central PMCID: PMC7744649.
6. Gupta H, Chandratre K, Sinha S, Huang T, Wu X, Cui J, Zhang MQ, Wang SM. Highly diversified core promoters in the human genome and their effects on gene expression and disease predisposition. BMC Genomics. 2020 Nov 30;21(1):842. doi: 10.1186/s12864-020-07222-5. PubMed PMID: 33256598; PubMed Central PMCID: PMC7706239.
7. Sinha S, Wang SM. Classification of VUS and unclassified variants in BRCA1 BRCT repeats by molecular dynamics simulation. Comput Struct Biotechnol J. 2020;18:723-736. doi: 10.1016/j.csbj.2020.03.013. eCollection 2020. PubMed PMID: 32257056; PubMed Central PMCID: PMC7125325.
8. Guo M, Sinha S, Wang SM. Coupled Genome-Wide DNA Methylation and Transcription Analysis Identified Rich Biomarkers and Drug Targets in Triple-Negative Breast Cancer. Cancers (Basel). 2019 Nov 4;11(11). doi: 10.3390/cancers11111724. PubMed PMID: 31690011; PubMed Central PMCID: PMC6896154.
9. Bhaskaran SP, Chandratre K, Gupta H, Zhang L, Wang X, Cui J, Kim YC, Sinha S, Jiang L, Lu B, Wu X, Qin Z, Huang T, Wang SM. Germline variation in BRCA1/2 is highly ethnic-specific: Evidence from over 30,000 Chinese hereditary breast and ovarian cancer patients. Int J Cancer. 2019 Aug 15;145(4):962-973. doi: 10.1002/ijc.32176. Epub 2019 Feb 13. PubMed PMID: 30702160; PubMed Central PMCID: PMC6617753.
10. Verma S, Singh A, Kumari A, Pandey B, Jamal S, Goyal S, Sinha S, Grover A. Insight into the inhibitor discrimination by FLT3 F691L. Chem Biol Drug Des. 2018 May;91(5):1056-1064. doi: 10.1111/cbdd.13169. Epub 2018 Feb 12. PubMed PMID: 29336115.
11. Sinha S, Verma S, Singh A, Somvanshi P, Grover A. Simulation Based Investigation of Deleterious nsSNPs in ATXN2 Gene and Its Structural Consequence Toward Spinocerebellar Ataxia. J Cell Biochem. 2018 Jan;119(1):499-510. doi: 10.1002/jcb.26209. Epub 2017 Jul 11. PubMed PMID: 28612427.
12. Singh A, Grover S, Sinha S, Das M, Somvanshi P, Grover A. Mechanistic Principles Behind Molecular Mechanism of Rifampicin Resistance in Mutant RNA Polymerase Beta Subunit of Mycobacterium tuberculosis. J Cell Biochem. 2017 Dec;118(12):4594-4606. doi: 10.1002/jcb.26124. Epub 2017 Jun 9. PubMed PMID: 28485504.
13. Verma S, Singh A, Kumari A, Goyal S, Jamal S, Sinha S, Grover A. Dissecting the role of mutations in chymase inhibition: Free energy and decomposition analysis. Gene. 2017 Apr 20;609:68-79. doi: 10.1016/j.gene.2017.01.030. Epub 2017 Jan 25. PubMed PMID: 28131820.
14. Sinha S, Goyal S, Somvanshi P, Grover A. Mechanistic Insights into the Binding of Class IIa HDAC Inhibitors toward Spinocerebellar Ataxia Type-2: A 3D-QSAR and Pharmacophore ModelingApproach. Front Neurosci. 2016;10:606. doi: 10.3389/fnins.2016.00606. eCollection 2016. PubMed PMID: 28119557; PubMed Central PMCID: PMC5223442.
15. Sinha S, Tyagi C, Goyal S, Jamal S, Somvanshi P, Grover A. Fragment based G-QSAR and molecular dynamics based mechanistic simulations into hydroxamic-based HDAC inhibitors against spinocerebellar ataxia. J Biomol Struct Dyn. 2016 Oct;34(10):2281-95. doi: 10.1080/07391102.2015.1113386. Epub 2016 Mar 4. PubMed PMID: 26510381.
16. Sehrawat A, Sinha S, Saxena A. Helicobacter pylori neutrophil-activating protein: a potential Treg modulator suppressing allergic asthma?. Front Microbiol. 2015;6:493. doi: 10.3389/fmicb.2015.00493. eCollection 2015. PubMed PMID: 26082756; PubMed Central PMCID: PMC4450655.
17. Tandon A, Sinha S. Structural insights into the binding of MMP9 inhibitors. Bioinformation. 2011 Jan 22;5(8):310-4. doi: 10.6026/97320630005310. PubMed PMID: 21383916; PubMed Central PMCID: PMC3046033.
Contact details:
Ph: +853-63474272, +91-9873554950
Email: siddharths@umac.mo, siddhartha.teri@gmail.com