Research

His previous studies focused on genomics in human and animal models, including

• Human genome, Drosophila genome and hybrid rice genome coding gene annotation
• Transcriptomics of hematopoietic cell development
• Abnormal gene expression and new fusion genes in leukemia
• Genome-scale antisense RNA mapping
• Evolutionary origin of miRNA genes
• New technology development in genome research

His recent research focuses on the application of genomics, bioinformatics and medical genetics approaches to study pathogenesis and early prevention of hereditary breast cancers, including

• Genetic diversity of genome regulatory regions in different ethnic populations
• Mutations in cancer genome regulatory region and their affected important genes
• New predisposition genes in familial breast cancer
• Ethnic-specific germline mutations in familial breast cancer
• Evolution of BRCA gene mutations in familial breast cancer
• Mechanism of BRCA mutation-caused genome instability
• Mechanism of cancer resistant in BRCA mutation carriers
• BRCA mutation in Chinese breast cancer
• Ethnic-specific BRCA mutation reference database
• Large-scale population screening for BRCA mutation carrier identification
• RNA world